The Zona Río is home to most of the regional headquarters for commercial and financial businesses and health services.

The city's largest mall, Plaza Río Tijuana, the central market, and the majority of Tijuana's larger hotels and upscale restaurants are also located here, along Zona Río's three main avenues, Paseo de los Héroes, Avenida Padre Kino and Boulevard General Rodolfo Sánchez Taboada.

[3] Although being comparatively small in comparison with other Mexican cities main business districts, such as those of Monterrey and Guadalajara, Zona Río has notable skyscrapers, which due to the relative distance between them, are very prominent.

Along this avenue are located most of the financial, commercial, and touristic businesses of Zona Río and the entire city.

Insurance companies, numerous banks, such as BBVA-Bancomer and Banamex, and shopping squares, such as Plaza Río Tijuana, the largest mall in the city, have their headquarters in this avenue.

In contrast to Paseo de los Héroes or Aguas Calientes, this is not one of the main avenues of the whole city, but rather only of Zona Río.

This avenue is the main gastronomical corridor of Zona Río, offering the widest variety of gastronomy in the entire city.