The Zosimades were six brothers: They were born in Ioannina, a city that was under Ottoman rule and a major center of the Greek Enlightenment that time.
After Theodosis' death (1793), he wrote in his testament that they should financially support the education of their home city Ioannina.
Another huge donation went for the National Library, of Adamantios Korais, one of the major contributors of the Greek Enlightenment movement.
During the following outbreak of the Greek War of Independence (1821–1830) the remaining Zosimades became active members of the patriotic organization Philiki Etaireia and supported financially the struggle.
Zosimades also completely financed the erection of the Monetary Museum of Athens, donating their personal collection of Ancient Greek and Roman currency, as well as the orphanage in Patmos.