The Cathedral of Saint John of Nepomuk (Serbian Cyrillic: Катедрала светог Ивана Непомука, romanized: Katedrala svetog Ivana Nepomuka; Hungarian: Nepomuki Szent Jánosszékesegyház; Slovene: Stolnica svetega Janeza Nepomuka) is a Roman Catholic Cathedral in Zrenjanin, Serbia.

It is the seat of the Roman Catholic Diocese of Zrenjanin that covers the territory of Serbian Banat.

For the duration of the Ottoman rule (1552–1718) there stood a mosque, but was razed down by the Austrians following Turkish withdrawal from the city and Banat.

The construction of the present-day cathedral commenced in 1864 by the project of Franz Xaver Brandeisz, who also built several churches in Banat, and lasted four years.

The interior was decorated by Josef Goigner from Tyrol and the cathedral features a pipe organ made in Timișoara, in 1907.