Muhammad Zuhair Masharqa (Arabic: زهير مشارقة; 1938 – 23 April 2007) was a Syrian politician who served as Vice President of Syria from 1984 to 2006.

[4] Masharqa was appointed to the cabinet in 1978 as Minister of Education and became vice president for Domestic Affairs on 11 March 1984.

[4][5] He was the country's longest serving vice president, in office from 1984 to 2006, and was particularly noted for his loyalty to Hafez al-Assad.

After the death of Assad in 2000, a 9-member committee was formed to oversee the transition period, and Masharqa was among its members.

[3] Masharqa died due to a massive heart attack in Damascus on 23 April 2007.