She was born in former Czechoslovakia, which she left in 1948 with her mother after surviving two years at Theresienstadt concentration camp during World War II.
She has filmed most of her documentaries in the Czech Republic and other European countries, and her topics have been the Holocaust of World War II and postwar history.
During World War II Zuzana, her brother and her parents, Viktor and Marie Pick, were imprisoned for two years in the Terezín concentration camp.
After working as a writer and translator, in 1986 Pick began to make her first film Terezin Diary (completed in 1989).
Her 2006 adaptation of her brother's 1982 play The Unlucky Man in the Yellow Cap (in original Czech Smolař ve žluté čepici ), was performed at the FringeNYC festival in August 2006.