[5] The Zymagotitz River's watershed is within the traditional territory of the Tsimshian Kitsumkalum people.

Part of the watershed is currently under negotiation for aboriginal title according to the British Columbia Treaty Process, under which the Kitsumkalum First Nation is in the fifth of six stages.

[13] The Zymagotitz River's watershed's land cover is classified as 37.7% Coniferous, 25.1% Barren, 14.8% Snow/Glacier, 9.9% Herb, and 8.1% Shrub.

[5] The Indian reserve Zimagord 3, of the Kitsumkalum First Nation,[14] is located near the mouth of the Zymagotitz River.

[16] Much of the Zymagotitz River's watershed has been subject to logging since the 1950s, including extensive clearcutting starting in the 1970s.