The Žiedupė (or Žiedupys) is a river of Kėdainiai district municipality, Kaunas County, central Lithuania.

It begins 2 kilometres (1.2 mi) north to Josvainiai, nearby Šingaliai village.

It flows mostly southwards and meets the Šušvė nearby Plaktiniai village.

Josvainiai village, Pažiedupys and Plaktiniai are located on the banks of the Žiedupė.

The name Žiedupė is a compound noun and derives from the Lithuanian words žiedas ('flower, blosom' or 'ring') and upė ('river').