[3] Further studies[4] showed that patients receiving medication to lower blood glucose had lasting improvement in 1,5-AG levels.

[5][6] In 2006, 1,5-AG showed its most compelling clinical use when it was demonstrated that an assay (GlycoMark, developed by Nippon Kayaku, Inc.) for postprandial hyperglycemia was able to differentiate two patients who had similar, near goal, hemoglobin A1c values, yet very different glucose profiles as shown by continuous blood glucose monitoring - one of the patients having excessive glycemic variability.

[15] The GlycoMark test is cleared by the FDA to be sold and marketed for the intermediate term monitoring of glycemic control in people with diabetes.

It is available through most major reference laboratories, including Quest Diagnostics and Labcorp or may be performed in a hospital or physician's office.

[16] The assay can be run on almost any open chemistry analyzer, including those found in physician office laboratories.

The amount of hydrogen peroxide is detected by colorimetry using peroxidase, and is in direct relationship to the serum 1,5-AG concentration.

Those with values below 10 μg/mL could benefit from nutritional counseling, and medications which target post meal glucose spikes, such as pramlintide, exenatide, sitagliptin, saxagliptin, repaglinide or rapid acting insulins.