The 105th Independent Brigade of the Territorial Defense Forces (Ukrainian: 105-та окрема бригада територіальної оборони) is a military formation of the Territorial Defense Forces of Ukraine in Ternopil Oblast.

On 4 March, Ternopil Oblast governor Volodymyr Trush announced that the brigade was at its full strength.

Its soldiers were tasked with defense of critical infrastructure, manning roadblocks and helping postal workers deliver pensions.

[7] By April 2022, units of the brigade were involved in combat missions near in Kharkiv Oblast, including near Barvinkove.

[8][9] Units of the brigade were stationed at the Kupiansk direction in the Kharkiv Oblast between October 2022 and March–April 2023.