[4] From 11 to 15 June a rifle company of the 127th Territorial Defense Battalion held training exercises for reservists in Desnianskyi District.

[8] During 14–19 April 2019 another larger scale training exercise for officers of headquarters and battalions was held, where they planned defending Kyiv.

[14] When the full-scale Russian invasion of Ukraine began on 24 February 2022, the brigade was fully filled with reservists who manned hundreds of roadblocks.

[16] On 14 April 2022, Commander-in-Chief of the Armed Forces of Ukraine Valerii Zaluzhnyi issued a decree that transformed the 241st Territorial Defense Battalion into the headquarters of the new 241st Brigade.

The brigade was active in the battles of Kyiv, Hostomel, Brovary, Moshchun, Bucha, Irpin, and took part in combat in Chernobyl.

During a military oath ceremony, Vitali Klitschko noted that 7 members of Kyiv City Council joined the company.

[23] In September 2022, a unit of the 112th Brigade took part in the recapture of Shevchenkove amid a Ukrainian counteroffensive in Kharkiv Oblast.

[24] The Kyiv territorial defense units were the first storm the Russian positions in the village of Mykolaivka [uk] on the morning of 7 September 2022, thus launching the Ukrainian offensive in the Chuhuiv Raion from which Shevchenkove was taken.

[27] On 19 April 2023, the Come Back Alive foundation announced that brigade had received three pick-up trucks, radios, generators, Starlink terminals and other equipment for the "Long arms of TrO" project deigned to give 120 mm mortars to those units.