The 121st Independent Brigade of the Territorial Defense Forces (Ukrainian: 121-та окрема бригада територіальної оборони) is a military formation of the Territorial Defense Forces of Ukraine in Kirovohrad Oblast.

Colonel Dmytro Zavorotniuk went to command 101st Territorial Defense Brigade.

[5] 174th battalion spent late spring and early summer in vicinity of Sievierodonetsk and Lysychansk.

[11] Other units of the brigade were stationed in Kherson Oblast where they captured enemy equipment.

[14] On 11 May 2023 units of the brigade held joint training with Ukrainian Naval Aviation.