The 110th Independent Brigade of the Territorial Defense Forces (Ukrainian: 110-та окрема бригада територіальної оборони) is a military formation of the Territorial Defense Forces of Ukraine in Zaporizhzhia Oblast.

In December 2018, soldiers of the brigade began taking part in oath ceremonies.

The brigade had planned to have close to 2,700 serviceman divided between six battalions located in Zaporizhzhia, Melitopol, Berdiansk, Polohy, and Kamianka-Dniprovska.

[2] The brigade was assigned to the southern defense sector on the evening of 25 February.

[3] Towards the end of April 2022, commander Viacheslav Vlasenko was removed from his position.