The regimental headquarters was organized on 10 November 1923 and federally recognized at New Orleans, Louisiana.

The regiment, less the Georgia elements, was called up to perform relief and guard duties associated with the flooding of the Mississippi River from 26 April to 19 June 1927.

It conducted summer training most years at Fort Oglethorpe, Georgia, from 1921 to 1939, and at Camp McClellan, Alabama, in 1924, 1926–28, and 1933.

Regimental elements used to form the 101st and 105th Separate Battalions, Coast Artillery (Antiaircraft).

Saso, commanding, Camp Wheeler, Ga., 9 February 1918 2nd Squadron Reconnaissance Surveillance and Target Acquisition (RSTA), 108th Cavalry Regiment (LA ARNG) was mobilized on 5 January 2010 for deployment as part of the 256th IBCT.