The regiment performed duty near Evansville, Indiana, until June 7.
The men remained on duty at Beverly until July 24 and were mustered out of service on August 2, 1861.
The 10th Indiana Infantry was reorganized at Indianapolis and mustered in for three years service on September 18, 1861.
The regiment was attached to Thomas' Command, Army of the Ohio, October–November 1861.
2nd Brigade, 1st Division, III Corps, Army of the Ohio, to November 1862.
2nd Brigade, 3rd Division, Center, XIV Corps, Army of the Cumberland, to January 1863.
2nd Brigade, 3rd Division, XIV Corps, Army of the Cumberland, to October 1863.
Garrison duty, Chattanooga, Tennessee, Department of the Cumberland, to April 1864.
Moved to Louisville, Kentucky, then to Nashville, Tennessee, February 11-March 2.
March to Iuka, Mississippi, then to Tuscombia, Alabama, and duty there until August.
March to Louisville, Kentucky, in pursuit of Bragg August 20-September 26.
Passage of the Cumberland Mountains and Tennessee River and Chickamauga Campaign August 16-September 22.
Tunnel Hill, Buzzard's Roost Gap and Rocky Faced Ridge February 23–25.
Operations on line of Pumpkin Vine Creek and battles about Dallas, New Hope Church, and Allatoona Hills May 25-June 5.