The 10th Regiment Indiana Cavalry, also designated the 125th Indiana Regiment, was a Cavalry Regiment raised in southern Indiana to fight in the American Civil War.

The 10th Regiment Indiana Cavalry was organized at Columbus and Vincennes, Indiana, in the winter of 1863 through the spring of 1864.

In command of the Regiment was Colonel Thomas N. Pace.

The Regimental Companies were: Once the Regiment was moved into Pulaski, Tennessee, the 10th Indiana Cavalry Regiment was broken up into detachments for a variety of missions.

Regiment lost during service 1 Officer and 20 Enlisted men killed and mortally wounded and 4 Officers and 157 Enlisted men by disease.