It was assigned a military district within the western part of the Commonwealth that comprised Westmoreland, Washington, Somerset, Blair, Fayette, Indiana, Beaver, and Greene Counties.

[3] The 10th Regiment participated in the annual State encampments of the National Guard and was activated in response to domestic labor disturbances in 1877, 1891, 1892, 1902, and 1916.

While they were initially based out of Camp Dewey near Malate, Manila, the Regiment participated in numerous battles throughout the campaign to include: Malate, Manila, Filipino Outbreak, La Loma, Caloocan, San Francisco del Monte, Tuliahan River, Meycauayan, Marilao, Bocaue, Guiguinto,and Malolos.

[3] On June 22, 1916, the Regiment was mobilized again for active service to El Paso, Texas in support of the Pancho Villa Expedition.

[3] During the First World War, the regiment was mobilized at home stations on July 15, 1917, and drafted in while into the Army of the United States on August 5.

The entire regiment was called up to perform relief duties in connection with the flooding of the Schuylkill and Susquehanna Rivers in April 1936.