In July 1911, the IRT had withdrawn from the talks, and the Brooklyn Rapid Transit Company (BRT) was to operate on Lexington Avenue.

[16][17] On March 20, 1991, a woman was raped behind a pile of debris in the subway passageway connecting the 34th Street–Herald Square and 42nd Street–Bryant Park stations under Sixth Avenue during rush hour, which had entrances at 38th Street.

In response, on March 28, 1991, the NYCTA ordered the closing of the 15 most dangerous passageways in the system within a week, which the Transit Police and citizen advocacy groups had called for since the previous year.

Work on these ten renovation projects was estimated to cost almost $146 million, and was scheduled to start later that year, and be completed in April 2004.

The renovation projects made repairs to platforms, replaced or refurbished stairways, installed new lighting and tiles, and reconfigured fare control areas.

[23] In May 2018, New York City Transit Authority President Andy Byford announced his plan subway and bus modernization plan, known as Fast Forward, which included making an additional 50 stations compliant with the Americans with Disabilities Act of 1990 during the 2020–2024 Metropolitan Transportation Authority (MTA) Capital Program to allow most riders to have an accessible station every two or three stops.

[26] In December, the MTA announced that an additional twenty stations, including 110th Street, would be made ADA-accessible as part of the Capital Program.

The artwork at this station is a mosaic entitled Un Sábado en la Ciento Diez (A Saturday on 110th), by Manuel Vega in 1996.

[39][40][41] The entrance on the northbound platform to the southeastern corner of 111th Street and Lexington Avenue was closed due to safety reasons in 1992[22] and was subsequently slabbed over.