On 9 September 1349, an earthquake sequence began in Italy's Apennine Mountains that severely affected the regions of Molise, Latium and Abruzzo.

Probably four moderate-large earthquakes[2] devastated towns and villages across the central Italian Peninsula, with damage even reported in Rome.

[3] The first earthquake, with an estimated magnitude of 6.7, struck on 9 September in the north-west Campania southeast of the Molisano town of Venafro.

Both quakes caused widespread damage to not just towns and cities but infrastructure like Roman aqueducts and bridges.

[1] The side of the four-story Colosseum collapsed towards the caelian hills, leaving a massive mound of travertine and tufa rubble Rome later quarried for construction materials.