The team was led by second-year head coach Johnny Metras.
[1] The Mustangs had previously played Canadian university football, but the intercollegiate sport was suspended in Canada due to the war.
[2][3] Prior to the start of the 1941 season, Western Ontario had not lost a game in two years against Canadian opponents.
The 1941 Western Ontario team included only one American player, John "Bomber" Douglas of Detroit.
[5] Joe Krol scored three touchdowns for the Mustangs in their November 1 game.