The 1964–65 season was Club Deportivo Cruz Azul's 38th season in existence, the 5th season in the football club's history as a professional team and the 1st season in the top flight of Mexican football.

The team competed in the Primera División and Copa México.

Cruz Azul made his Primera División debut on 6 June 1964 against Monterrey.

[1] The club was managed by Hungarian Jorge Marik in his fourth season with the team.

[2] Source: RSSSF