The 1965–66 Honduran Liga Nacional season was the inaugural edition of the Honduran Liga Nacional.
The format of the tournament consisted of a double round-robin schedule.
won the title after defeating España 2–0 in the last round at El Progreso.
[1] In 1964, a triangular tournament was organized between three clubs from the Liga Dionisio de Herrera between C.D.S.
España was interrupted for several minutes due to a deflated ball.