Humphrey's running mate was Senator Edmund Muskie of Maine, while Nixon ran with Governor Spiro Agnew of Maryland.

Humphrey carried Massachusetts in a landslide, taking 63.01% of the vote to Nixon’s 32.89%, a Democratic victory margin of 30.12%.

The American Independent candidate, Southern populist Governor George Wallace of Alabama, did not have a serious impact on the race.

While Humphrey did not reach Johnson’s level of support, his 63.01% outperformed JFK and remains the third highest vote share any Democratic presidential candidate has ever received in the state — even though Humphrey was losing the election nationally, thus establishing the state’s reputation as a Democratic stronghold in the modern era.

Nevertheless, Nixon became the first Republican ever to win the White House without carrying Norfolk, Essex, Hampshire, Middlesex, Plymouth, and Worcester counties.