The 1977–78 Penn Quakers men's basketball team was a college basketball team that represented the University of Pennsylvania in the 1977–78 NCAA Division I men's basketball season.

The Quakers, coached by Bob Weinhauer, played in the Ivy League and had a 20–8 win–loss record.

Penn won the Ivy League regular season championship for the seventh time in nine years and participated in the 1978 NCAA Division I basketball tournament.

The Quakers defeated St. Bonaventure in the opening round[2] before falling to eventual National runner-up Duke, 84–80, in the East Regional Semifinal.

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