The 1979–80 Penn Quakers men's basketball team represented the University of Pennsylvania as a member of the Ivy League during the 1979–80 NCAA Division I men's basketball season.

Led by head coach Bob Weinhauer, the Quakers played their home games at The Palestra in Philadelphia.

A year after reaching the Final Four, Penn again finished as Ivy League champions by defeating co-champion Princeton in a play-in game to receive an automatic bid to the NCAA tournament.

12 seed in the Mideast region, the Quakers defeated No.

5 seed Washington State in the opening round, before losing to No.