The 1979–80 Holy Cross Crusaders men's basketball team represented the College of the Holy Cross during the 1979–80 NCAA Division I men's basketball season.

The Crusaders, led by head coach George Blaney, played their home games at the Hart Center and were members of the East Coast Athletic Conference – North.

They finished the season 19–11, 4–0 in ECAC-South play to finish in third place.

They defeated Vermont, Maine, and Boston University to win the ECAC North tournament and earn the conference's automatic bid to the NCAA tournament.

11 seed in the East region, they lost to Iona in the opening round, 84–78.