The 1980–81 season was Juventus Football Club's 83rd in existence and 79th consecutive season in the top flight of Italian football.

In July 1980, after fourteen years of a transfer ban of foreigners, Irish midfielder Liam Brady transferred from Arsenal to Juventus and helped Juventus finish the season as Serie A champions.

They also participated in UEFA Cup, being defeated at home in second round.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.