The 1980–81 Villanova Wildcats men's basketball team represented Villanova University during the 1980–81 NCAA Division I men's basketball season.
The team played its home games at Villanova Field House in Villanova, Pennsylvania, and was a member of the Big East Conference.
The team finished tied for 3rd in the conference regular season standings and received a bid to the NCAA tournament before falling to No.
1 seed and eventual Final Four participant Virginia.
Villanova finished with a 20–11 record (8–6 Big East).