UNAM won the final round, becoming CONCACAF club champions for the first time in their history.

Santiagueño advanced to the third round after Cartaginés withdrew from the competition Comunicaciones won 5–2 on aggregate.

Central America Zone Torneo Centroamericano de Concacaf 1980 Marathón won 5–1 on aggregate.

North America Zone UNAM won 4–1 on aggregate; advanced to the final round.

Central America Zone Torneo Centroamericano de Concacaf 1980 UNAH won 1–0 on aggregate.