The 1990 Louisville Cardinals football team represented the University of Louisville as an independent during the 1990 NCAA Division I-A football season.
Led by the sixth-year head coach Howard Schnellenberger, the Cardinals compiled a record of 10–1–1 and defeated Alabama in the Fiesta Bowl.
Browning Nagle threw for a Fiesta Bowl record 451 yards and 3 touchdowns as the Cardinals routed the Crimson Tide, 34–7.
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