2,2-Dichloro-1,1,1-trifluoroethane or HCFC-123 is considered as an alternative to CFC-11 in low pressure refrigeration and HVAC systems, and should not be used in foam blowing processes or solvent applications.

HCFC-123 will eventually be phased out under the current schedule of the Montreal Protocol.

Developing countries can continue to use It in new equipment until 2030 and will be produced for use in service there until 2040.

HCFC-123 is also used as a testing agent for bypass leakage of carbon adsorbers in gas filtration systems, and as the primary chemical in Halotron I fire-extinguishing agent.

2,2-Dichloro-1,1,1-trifluoroethane can be produced by reacting tetrachloroethylene with hydrogen fluoride in the gas phase.