2,5-Xylidine is an organic compound with the formula C6H3(CH3)2NH2.

Commercially significant derivatives include Solvent Yellow 30, Solvent Red 22, Acid Red 65, and Solvent Red 26.

[1] Like many xylidines, it is prepared by nitration of the corresponding xylene followed by reduction of the nitroxylene.

Reduction can be effected with HCl/Fe, but usually is achieved by catalytic hydrogenation: It is mutagenic and tumor-inducing.

Acute toxicity of xylidines is modest as indicated by LD50 (rats, oral) are in the range 0.1-1 g/kg.