2-Aminothiazole

It possesses an odor similar to pyridine and is soluble in water, alcohols and diethyl ether.

[3] Like the parent, 2-aminothiazoles are often produced by the condensation of thiourea and an alpha-halo ketone.

[4][5][6] In an adaptation of the Robinson-Gabriel synthesis, a 2-acylamino-ketone reacts with phosphorus pentasulfide.

Synthetic aminothiazoles - compounds containing the parent 2-aminothiazole as a subunit - are used in medicinal chemistry.

Some examples are abafungin, acotiamide, amiphenazole, amthamine, avatrombopag, aztreonam, cefepime, cefixime, ceftizoxime, ceftiofur, ceftibuten, cefpirome, famotidine, meloxicam, and pramipexole.

Skeletal formula of aminothiazole
Space-filling model of the aminothiazole molecule
NFPA 704 four-colored diamond Health 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroform Flammability 0: Will not burn. E.g. water Instability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogen Special hazards (white): no code
Hantsch Thiazole Synthesis
Hantsch Thiazole Synthesis