They also won the AFC South Division Championship for the fourth time in a row, and they defeated the Kansas City Chiefs in the Wild Card round and the Baltimore Ravens in the Divisional round, before winning the AFC Championship, beating the New England Patriots 38–34 to advance to Super Bowl XLI, in which they dominated the Chicago Bears, winning 29–17 on February 4, 2007, at Dolphin Stadium.

[18] The offseason marked the dissolution of the trio of Edgerrin James, Peyton Manning, and Marvin Harrison, affectionately nicknamed the "Triplets" by Colts fans.

A 1-yard touchdown run by Giants RB Brandon Jacobs made the game interesting in the final minutes, but Indianapolis responded with one last field goal and timely defensive plays down the stretch, and were able to seal the victory.

Houston showed signs of life in the fourth quarter as QB David Carr completed a 33-yard touchdown pass to TE Owen Daniels.

The Texans answered on Carr's 1-yard touchdown pass to TE Mark Bruener, but the Colts scored yet again, this time on a 3-yard TD run by RB Ran Carthon.

After a scoreless third quarter, kicker Martin Gramatica, filling in for the injured Adam Vinatieri, made a 20-yard field goal early in the fourth to give Indianapolis the lead, 17–14.

Illustrating perfectly the back-and-forth nature of the contest, the lead changed hands once again as DB Justin Miller returned the ensuing kickoff 103 yards for a touchdown to quickly move all the momentum to New York's side.

Showing the resolve that allowed them to come from behind in their two previous games, the Indianapolis offense delivered what turned out to be the game-clinching score with only five minutes left in the fourth quarter on a 2-yard touchdown pass from Peyton Manning to WR Reggie Wayne to give the Colts a 14–13 lead.

The Broncos sat atop the AFC West standings with a 5–1 record thanks in large part to a strong running game and a dominating defense that had only allowed two touchdowns on the season.

The Colts had a 7-point lead near the end of the half, but Buffalo swung the momentum their way as Terrence McGee returned a fumble 68-yards for a touchdown to tie the game at 10.

Colts QB Peyton Manning threw two interceptions and one of those was returned for a touchdown by Cowboys OLB Kevin Burnett early in the second half.

After a couple of punts by both teams, Peyton Manning & Co. pushed the Cowboys deep in their own territory thanks to the great rushing by rookie RB Joseph Addai.

The Colts reached the 4-yard line, and on third down, Manning attempted a pass to the endzone, but in a controversial situation, SS Roy Williams nudged TE Dallas Clark near the end zone, and while Clark fell down, Williams intercepted a Peyton Manning pass for the second time in his career, and gave the Cowboys the ball at their own 7-yard line.

On the following possession, the Colts ran the ball 13 times with no passes and Joseph Addai had the last 8 carries on that drive including another 4-yard scamper, his fourth touchdown of the game.

During this game, the Colts lost SS Antoine Bethea, TE Dallas Clark and OT Ryan Diem all to injuries in the first half, and they did not return.

The Colts' next possession uncharacteristically ended abruptly when Peyton Manning's pass intended for TE Bryan Fletcher was intercepted by OLB Keith Bulluck with 31 seconds left in the half.

20 seconds later, Titans QB Vince Young connected with WR Drew Bennett for a 20-yard touchdown pass to shrink the Colts' lead to 4 points.

Hoping to rebound from their blowout road loss to the Jaguars, the Colts went home for a Monday Night Football matchup with the Cincinnati Bengals.

However, Houston managed to pull off a huge upset with Kris Brown's game-winning 48-yard field goal as time expired, giving Indianapolis their first ever loss against them.

With less than ten minutes remaining in the last game of the season for Miami, they finally found the end zone when Cleo Lemon completed a 6-yard touchdown pass to TE Randy McMichael.

In the third quarter, the Colts struggled to find the end zone, yet it provided Adam Vinatieri to cement his immense value to the team as a free agent pickup.

With the win, the Colts improved their overall record to 14–4 this season and would advance to the AFC Championship Game to play against the New England Patriots at the RCA Dome in Indianapolis.

Patriots QB Tom Brady fumbled the handoff to RB Laurence Maroney, the ball started rolling towards the goal line, went through a few pairs of Colts defenders' hands, and G Logan Mankins fell on it for a touchdown.

After that touchdown catch, the Colts elected to go for the two-point conversion, and Manning completed a pass in the end zone to WR Marvin Harrison to tie the game at 21.

Three plays later, rookie RB Joseph Addai ran right up the middle for a 3-yard touchdown to put the Colts up by 4 points, and give them their first lead of the game, 38–34.

[23] With the win, Indianapolis improved their overall record to 15–4 that season and would move on to face the NFC champion Chicago Bears in Super Bowl XLI at Dolphin Stadium.

Two weeks after their record-breaking comeback in the AFC Championship Game against the Patriots, the Colts flew to Dolphin Stadium for Super Bowl XLI against the NFC Champion Chicago Bears.

The drive ended with a 53-yard touchdown pass from Peyton Manning to WR Reggie Wayne, but punter Hunter Smith mishandled the snap on the extra point and kicker Adam Vinatieri could not convert the PAT.

On the second play of the drive, FS Bob Sanders caused RB Cedric Benson to fumble the football, and the Colts recovered.

Rookie RB Joseph Addai finished the game with 19 carries for 77 yards rushing and had 10 catches which is today four shy of the Super Bowl record.