The 2004 Nicholls State Colonels football team represented Nicholls State University as a member of the Southland Conference during the 2004 NCAA Division I-AA football season.
Led by first-year head Jay Thomas, the Colonels compiled an overall record of 5–5 with a mark of 2–3 in conference play, placing fourth in the Southland.
Nicholls State played home games at John L. Guidry Stadium in Thibodaux, Louisiana.
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