The knockout stage of the 2005–06 UEFA Champions League featured the 16 teams who finished in the top two positions in each of the eight groups in the group stage.
The first matches of the round of 16 were played on 21 February 2006 and the final was played on 17 May 2006 at the Stade de France in Saint-Denis, near Paris, France.
3–3 on aggregate; Villarreal won on away goals.
4–4 on aggregate; Juventus won on away goals.
2–2 on aggregate; Villarreal won on away goals.