The 2005 CAF Champions League was the 41st edition of the CAF Champions League, the Africa's premier club football tournament prize organized by the Confederation of African Football (CAF).

Al Ahly of Egypt defeated Étoile du Sahel of Tunisia in the final to win their fourth title.

1 Wallidan FC were withdrawn by the Gambia Football Federation.

The first leg was played on 24–25 September and the second on 15–16 October.

The top scorers from the 2005 CAF Champions League are as follows: