The 2005 Saint Francis Cougars football team represented the University of Saint Francis, located in Fort Wayne, Indiana, in the 2005 NAIA football season.
The Cougars played their home games at Bishop John M. D'Arcy Stadium and were members of the Mid-States Football Association (MSFA) Mideast League (MEL).
The Cougars finished in 1st place in the MSFA MEL division, and they received an automatic bid to the 2005 postseason NAIA playoffs.
In the postseason playoffs, the Cougars advanced to the national championship game where they lost to the Fighting Saints of Carroll, 27-10.
(13-1 overall, 7-0 conference) The 2005 season saw a rematch of the 2004 NAIA championship game.