Quarterback-turned-wide receiver Paul Thompson was converted back to quarterback and led the Sooners to an 11–3 season capturing the Big 12 Championship and competing in a BCS bowl game.

On July 11, 2007, the NCAA announced a finding of "failure to monitor" the employment of student athletes and handed out penalties, most of which were extensions of punishments already set in place by the university.

In addition to the seniors leaving, running back Adrian Peterson left early for the NFL Draft and three other players were set to be on medical redshirt for the upcoming season.

[20] The 2007 team captains were Joe Jon Finley, Allen Patrick, Lewis Baker, Marcus Walker and Jacob Gutierrez.

The last time Oklahoma played North Texas was in 2003, when the Sooners held the Mean Green to 154 yards of total offense in a 37–3 win.

The official attendance for the game was 84,472, the 50th consecutive sellout and the largest crowd ever to see an opener at Gaylord Family Oklahoma Memorial Stadium.

[35] The Sooners, after moving up a couple spots in both polls, took on Randy Shannon's Miami team in front of a record-breaking 85,357 people at Oklahoma Memorial Stadium.

[45] The Sooners' third game of the season brought in the Utah State Aggies of the Western Athletic Conference, led by head coach Brent Guy.

[63] The Sooners came back in the first quarter and scored two touchdowns on two big plays: a 29-yard run by Allen Patrick and a 46-yard pass to Juaquin Iglesias.

Three plays later, Wolfe made his second interception on Buffalo QB Cody Hawkins and returned it 28 yards to the Colorado 17.

The game will also feature one of the best match-ups of the year with Limas Sweed and Billy Pittman of the Longhorns facing against Oklahoma's excellent secondary.

McCoy threw one interception and Jamaal Charles lost a fumble inside the Oklahoma 5 yard-line on what would have most likely been a touchdown scoring run.

The Oklahoma defense held Texas to 61 rushing yards, their lowest total of the season (their previous low was 117 against Arkansas State).

[85] The match was highlighted by the play of a few notable Sooners including freshman running back DeMarco Murray, wide receivers Juaquin Iglesias and Malcolm Kelly, and quarterback Sam Bradford.

[90] After three games away from home, the Sooners returned to Norman to take on Gary Pinkel's undefeated Missouri Tigers in front of 85,041 fans.

On Missouri's next possession, Daniel attempted a handoff to Maclin but a miscommunication led to a fumble which was picked up by Oklahoma's Curtis Lofton and returned for a touchdown.

[113] Halfway through the third quarter, Oklahoma began their drive on their own 17 yard line with an 18-yard rush by DeMarco Murray that was followed a couple plays later by a 45 pass to Malcolm Kelly.

Auston English, who led the Big 12 in sacks, left the game in the second quarter to what was later found to be a hairline fracture in his ankle.

On the next possession, Bradford connected with tight end Jermaine Gresham for a 43-yard pass that set up a one-yard touchdown run for Murray.

Late in the 2nd quarter, Baylor quarterback Blake Szymanski threw a 75-yard touchdown pass to Thomas White to bring the score to 21–14.

Bradford connected with Joe John Finley for a 21-yard gain and Manuel Johnson on a 60-yard touchdown pass to give Oklahoma the 21 point advantage.

Oklahoma State's top receiver Adarius Bowman also suffered a knee injury in an earlier game and would also miss the Bedlam match.

After being set back five yards on a penalty, Savage rushed up the middle on the first play to get the touchdown and put the Cowboys within 11 points halfway through the third quarter.

Running back Allen Patrick ran for a career-best 202 yards after coming off his worst game of his career against Texas Tech.

Linebacker Curtis Lofton was named the Big 12 Defensive Player of the Week for his performance which included nine tackles and a forced fumble.

Even though this game was on a neutral field and Missouri had their star running back Tony Temple (who was injured for the first meeting), the #1 Tigers were 3-point underdogs to the eighth-ranked Sooners.

On Missouri's third possession, a combination of Chase Daniel passes and Tony Temple rushes carried the Tigers down to the Oklahoma 11 yard drive, where the Sooners' defense stepped up and forced a 28-yard Jeff Wolfert field goal.

The play was a double reverse; Jeremy Maclin ended up with the ball and passed it to Martin Rucker, who was wide open in the endzone.

At this point, the West Virginia Mountaineers had just lost their game to the Pittsburgh Panthers, meaning that the top two teams were in danger of losing.

The Sooners put together a drive in which every play that advanced the ball was a run (Bradford had one incomplete pass), eating over six minutes off of the clock.