The 2009–10 season was Sports Club Slavia Prague's 17th consecutive season in the Czech First League and 117th year in existence as a football club.

In addition to the domestic league, Slavia Prague participated in this season's editions of the Czech Cup, UEFA Champions League and UEFA Europa League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Source: [1] Source: Competitions Source: Competitions