The 2009–10 Women's A Basketball League of Serbia is the 4th season of the First Women's Basketball League of Serbia, the highest professional basketball league in Serbia.
It is also 66th national championship played by Serbian clubs inclusive of nation's previous incarnations as Yugoslavia and Serbia & Montenegro.
The League part of the season was played with 12 teams and play a dual circuit system, each with each one game at home and away.
The four best teams at the end of the regular season were placed in the Play Off.
The regular season began on 8 October 2009 and it will end on 21 March 2010.