The 2015–16 First Women's Basketball League of Serbia is the 10th season of the First Women's Basketball League of Serbia, the highest professional basketball league in Serbia.

It is also 72nd national championship played by Serbian clubs inclusive of nation's previous incarnations as Yugoslavia and Serbia & Montenegro.

Partizan is left the competition and moved in lower rank, and therefore stayed Bor in the league.

The four best teams at the end of the regular season were placed in the Play Off.

The regular season began on 10 October 2015 and it will end on 10 March 2016.