The second part of the season, referred to as "Superleague", featured inter-league play between four teams from the Adriatic League and four teams from the First Women's Basketball League of Serbia.

The regular season, which ran from 9 October 2010 to 19 February 2011, consisted of dual circuit play between nine teams.

The Superleague, which ran from 9 March 2011 to April 2011, consisted of dual circuit play between eight teams, four each from the Adriatic League and the First Women's Basketball League of Serbia.

The four best teams at the end of the regular season moved on to the playoffs.

The worst ranked team, ŽKK Kovin, was relegated to the Second League of Serbia.