A total of 67 clubs had been accepted to enter, after the withdrawal of Egaleo, Kalamata and Pyrsos Grevena and their relegation to Delta Ethniki.
The competition commenced on 4 September 2010 with the First Round and concluded on 30 April 2011 with the final, held at Olympic Stadium.
[1][2] The following 67 teams competed in First Round: Each tie in the knockout phase, apart from the quarter-finals and the semi-finals, was played by a single match.
The team that scored more goals on aggregate over the two legs advanced to the next round.
If no goals were scored during extra time, the winners were decided by a penalty shoot-out.