The competition started on 23 May 2010 with the matches of the First Round and will end in May 2011 with the Final.
The winner of this competition will earn a place in the second qualifying round of the 2011–12 UEFA Europa League.
FK Tauras Šiauliai received a bye to the Fifth Round.
The 4 winners from the previous round entered this stage of the competition.
Unlike the previous rounds of the competition, this was played over two legs.