Rumelange and Mondercange were relegated to the Division of Honour after finishing 13th and 14th in the previous season.
They were replaced by 2009–10 Division of Honour champions Wiltz 71 and runners-up Jeunesse Canach.
Käerjéng 97 as 12th-placed team had to compete in a single play-off match against 3rd-placed Division of Honour side Oberkorn.
Käerjéng 97 won the match 3–1 and thus retained their National Division status.
Hostert won the match after a penalty shootout, thus winning promotion to the league for the first time in their history.