The competition began on 10 November 2010 and ended 22 May 2011 with the Final from Ta' Qali Stadium.
The defending champions are Valletta, having won their 12th Maltese Cup last season and first since 2001.
Valletta were the defending champions, but lost in the Final to Floriana.
[1] For the second straight year, four teams will receive a bye directly into the quarterfinals.
Entering this round was the winner from the preliminary round along with the six Maltese Premier League clubs which finished last season between 5th and 10th place in the league, the remaining eight clubs from the First Division and the reigning Gozo First Division champions.