The 2010–11 Maltese Second Division started in September 2010 and will end in May 2011.
St. Patrick and San Gwann were relegated from the 2009–10 Maltese First Division.
Zejtun Corinthians, Mgarr United and Naxxar Lions were promoted from 2009–10 Maltese Third Division.
Decider for promotion to Maltese First Division 2011-12 A Decider was needed between St. Patrick and Mellieha because they both ended with 36 points.
Glenn Barry Scored the only Goal.