The 2015–16 Maltese Second Division started in September 2015 and ended in May 2016.
Msida Saint-Joseph F.C., Kirkop United F.C.
were relegated to the Maltese Third Division.
Marsa were crowned champions in the last game against Gharghur as they won 2–1.
[1] Additionally, Sirens lost the Derby against Mgarr United and handed the cup to the champions Marsa.