The 2010 Belarusian Premier League was the 20th season of top-tier football in Belarus.

Gomel, Granit Mikashevichi and Smorgon were relegated to the Belarusian First League after finishing the 2009 season in the last three places.

Torpedo Zhodino played a two-legged relegation play-off against SKVICH Minsk, the runners-up of 2010 Belarusian First League for one spot in the 2011 Premier League.

Torpedo Zhodino won the play-off 3–1 on aggregate and retained their spot in the top flight.

Updated to games played on 21 November 2010 Source: football.by Archived 2011-07-21 at the Wayback Machine