Before the start of the season, Brisbane's test centre Justin Hodges damaged an Achilles tendon at training, ruling him out for the entire year.
Halfway through the season, the Broncos' other superstar centre Israel Folau announced that he was quitting rugby league at the end of the year to take up Australian rules football with AFL expansion club, Greater Western Sydney.
The Broncos had agreed to terms for another superstar centre, Greg Inglis, to join them for 2011 but he reneged on the deal in the post season.
In round 10, the Broncos celebrated Corey Parker's 200th game in style with a 28–6 win over the Gold Coast Titans at Suncorp Stadium.
Brisbane then lost five of its last eight matches after the Origin period, but they did defeat the eventual premiers St. George Illawarra in Round 21.